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COVID-19 Check-in

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Comments

  • RxDawgRxDawg Posts: 2,922 ✭✭✭✭✭ Graduate
    edited April 2020

    I'd be very leery of remdesivir. It's investigational, who knows what this could do to you 5 years down the road. It should only be considered in the most extreme of critical cases. When death is imminent and you'r down to your last option. It's the hail merry. I'd wager < 1% of total COVID positive patients will be considered for this.

    It's also not commercially available. The physician has to contact the company directly and fill out a form to request the med for each patient individually.


    Not to bash you or anything, but like hydroxychloroquine, we might be rushing to use a med that can actually cause more harm than good. It's human nature to hope. As medical professionals you have to be careful not to misplace that hope. I've been around long enough where I've seen the next and greatest thing taken off the market later because it turned out to not be so great at all.

  • YaleDawgYaleDawg Posts: 7,269 ✭✭✭✭✭ Graduate

    What makes you leery of remdesivir over other nucleotide and nucleoside analogs used for viral infections the past 50 years? Main concern I've seen with this class of drugs is hepatotoxicity caused by disrupting mitochondrial DNA replication. If it can happen it's usually mild after long term use which we wouldn't see for COVID-19. I do agree we shouldn't rush anything which is why I support this drug going through clinical trials and market surveillance like normal. I'm more worried about chloroquine since it has a lot of severe drug interactions and can hurt people with heart, kidney, and liver problems.

  • YaleDawgYaleDawg Posts: 7,269 ✭✭✭✭✭ Graduate
    edited April 2020

    Yeah, sudafed and meth are nearly identical. That's why trials are important, but nucleotide analogs are generally considered safe. I'm just wondering if you had some inside information on remdesivir

  • dawgnmsdawgnms Posts: 5,357 mod

    Being his nick is @RxDawg I would bet he has a PharmD. So inside information would be a given.

  • Steve_ZissouSteve_Zissou Posts: 307 ✭✭✭ Junior

    PJackson still think this is a democrat hoax?

  • santabarbaradawgsantabarbaradawg Posts: 186 ✭✭✭✭ Senior

    Thanks . I feel alright, knot in the chest feeling was gone after 2 days,, just headache and cough, and slept for 16 hours today . The tiredness is the worst part.

  • Denmen185Denmen185 Posts: 7,504 ✭✭✭✭✭ Graduate

    I hope you and Kasey are right. Unfortunately here in Florida the Stay at Home doesn't start until midnight tonight so we are way behind. This "lock-down" is also very weak as, for example, churches are exempt and I live 1/2 a mile from a 1000+ church. My wife and I went on personal Stay at Home 2 weeks ago only going out (her) to get food once.

    A week ago I did a simple model on US Deaths and projected the first 1,000 death day 4/4, the first 2,000 day 4/11 and the 3,000 day 4/17 topping out at 3,800 4/29 with an April total of 80k. Obviously not good news and I sincerely hope i'm wrong.

This discussion has been closed.