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COVID-19 Check-in
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I'm looking for UGA masks. Any ideas???
Pricey
And 40% off. 🙃
Got them! Thxs
Thank you for respecting your fellow Dawg fans!
Some good news for therapeutic approaches dealing with COVID-19. Remdesivir was able to speed up recovery from 15 days to 11 days and decreased mortality from 11.6% to 8% based on a preliminary analysis of the data generated in clinical trial by the NIH (will be interesting to look at the full report). It is by no means a miracle cure, but it can help people and is an important proof of concept. We can target specific viral enzymes with rational based drug design to inhibit viral spread. There are other drugs being tested that target different viral proteins. If these end up working, they can be used with Remdesivir which will likely have a more potent effect on the virus.
Edit: the mortality rate difference just barely missed the cutoff for being statistically significant. We'll need to see results from other studies with mild and moderate cases to see if it truly has an effect in decreasing mortality.
You could tell that Fauci was excited because "proof of concept" was what finally started the ball rolling on treatments for HIV. The first drug opened the door for several more to pile on, ending what was once a death sentence. Every time Magic is interviewed on TV, I remember how I felt when he revealed he was HIV positive. 5-6 years earlier and he doesn't make it...
We'll probably see something similar with COVID. Cocktail therapies tend to be more effective than a single drug. Especially when dealing with things that can evolve quickly.
What's not clear to me is whether the "placebo" group were given anti-viral drugs as per current regime or were they given nothing? If they were given the baseline treatment to reflect current treatment then the 11.6 to 8 is very encouraging. If not the the Remdesivir may be no more effective than current anti-viral drugs!
So normal drug trials go like this:
Phase 1; Drug is given to several dozen healthy people to find out what the safest dose and at what concentration the drug becomes toxic and what common side effects might be.
Phase 2; does the drug have any biological effect on disease? up to a few hundred individuals with the disease are given the drug to see if it has any effect. Historically, most drugs fail at this stage.
Phase 3; this is the gold standard for determining a drug's benefit. Up to 3000 patients participate in a multi-site, controlled, randomized trial. Some will be given the experimental drug while others are given the best currently available treatment as a placebo.
Phase 4; market surveillance to make sure no harmful side effect was missed.
Anti-viral drugs typically target viral proteins so they tend to be very specific to what they are effective against. Usually only a few viruses that have highly similar target proteins.
I will be at the Virginia Statehouse protesting Gov. Ralph Northam on Wednesday.
A week ago his Health Commissioner floated the policy we would remain at Phase 3 until there is an approved vaccine.
80 percent of the deaths have been in nursing homes, but they will not provided the locations as they said they treat nursing homes as individual patients and said privacy laws does not allow that to be disclosed to the public.
Now to further delay the June 10 stay at home, they will count even positive test for the same individual as a new positive case. At the press conference today they indicated it could be 12 weeks or longer before we get to Phase 3.
Thanks for the down vote up above and here is your chance for a second down vote. Here is a second source from a mainstream media source.
BTW, UVA said they will probably wait until next month to make a decision about holding classes in the fall.
You're more optimistic than me in the pharmaceutical realm. Curing corona virus is essentially like curing the common cold. They've been trying to figure that one out since the beginning of medicine. But I sure hope they do.
My optimism lies in nature. Either nature will kill it off, or we will naturally become immune enough that it no longer holds the threat it does now. Sometimes an ecosystem is like a bucket of water. Once it gets kicked, it's got to rock around for a little bit before things settle back down.
You-do-you Bobcat. It is your right as a citizen of this wonderful country to peacefully protest. Adhere to social distancing, and keep it civil and I see nothing wrong with this, whether I agree with you or not. This stance taken by the VA state government is different than most. Wrong? I will let you know in 6-8 months...
Urgency is a b@#(h. I would argue that 1000x the money and the resources put into curing the common cold has already been put into this crap.
And my hope is for a therapeutic cocktail first - that turns the symptoms from lethal to rough, from rough to tough, from tough to minor.
A guy holding a stick doesn't terrify me like a dude with a .38 does.