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Comments
I saw all the posts on Sweden. I have a question for folks on this thread about Sweden. I'm scheduled to go to Sweden in July to pick up a sailboat and bring it back to the US (I sell boats or a living, which is pretty fun, yes).
Right now my flight is into Oslo, Norway, though I could change that to Stockholm, but it is a 6 hour drive from Stockholm and 1 hour from Oslo.
My Mom is in assisted living and it is interesting the amount of tissues she goes through.
I hear ya. Listen, I’m not denying my post was slanted. So have been dozens of other posts in this same thread. For instance, I mentioned ventilators. How much subtle flack has the POTUS received, IN THIS VERY THREAD, over HCQ and buying 29 million doses? All because of ONE publicized study out of Virginia. Did @CaliforniaDawg call out his fellow libt...s for posting their own “slanted” views that just happened to match his own hypocritical views? I think not, sir. One key difference between the two situations. The HCQ study out of UVA has been exposed as lacking in scientific method. The situations I referenced continue to stand as the most severe and therefor, the most inherently mismanaged.
There's no evidence to say if it does or doesn't work. That's what clinical trials are for. There was also a highly publicized study out of Brazil that was halted due to a quarter of the participants developing dangerous heart problems. A well known side effect of chloroquine and hydroxychloroquine. The study in France that started all this was with only 36 people and it wasn't even randomized. They were knowingly choosing who got the treatment and who did not which skews results.
Do you currently you allow your 12 year old to play with her friends? If so, then why would you be worried? If not, then why would you be worried? Seriously.
Cardiac issues with hydroxychloroquine are exceedingly rare. I've been prescribing it for well over 30 years. I was told that the culprit in Brazil was chloroquine, but I haven't verified, am I wrong?
off topic: I get to cut out cancers again, starting today; tension in my household is expected to diminish markedly.
Chloroquine is much worse. GENERALLY, hydroxychloroquine is safe. I'm surprised chloroquine is still even on the marked, but it could be an availability thing for smaller countries dealing with malaria. Or that one in a thousand patient that can tolerate chloroquine but not hydroxychloroquine for whatever reason.
There's actually a large list of meds that have come out and later down the road they found a chemical variant of the same drug that makes it more suitable for therapy. Sometimes it's more efficacious. Sometimes it has a better side effect profile. Sometimes it's neither and just a good way to slap a name brand on something and make a lot of money.... but that's for another topic.
(I know you know this Dragonslayer, I was just posting for the others)
When all of this COVID-19 is finally done for good, and at long last it is completely over with???
I sure DO hope that this event is but a once in a lifetime occurrence.
Amen to that!
Yeah it is rare for people taking it for RA and lupus to develop heart problems. Much more common to develop eye issues. The problem that's been coming up in these studies is patients being given doses that are between 500-600 mg instead of the 200-250 mg used for lupus and RA. In healthy people the therapeutic, toxic, and lethal doses are all close together. People with pre-existing heart issues are going to have a lower threshold for toxicity. COVID-19 is also causing heart problems in some people which could lower the toxic dose. We still need to do clinical trials to see if it can actually help treat COVID-19 and if the arrhythmia is only a problem for those with pre existing heart problems.
All of our kids out for just a quick ride around only our own block in our neighborhood with their Mama (that would be MY wife) from a few days ago. Fresh air with masks too. Our “Little DAWGS” of the future!!!
Even retinopathy is uncommon. We used to recommended ophthalmology exams every 6 months now most are getting it every year or two until they have been taking it for at least five years.. Loading doses appear safe as well. Like you, I don't think the data is sufficient to say it's effective,certainly doesn't appear to be in severe cases presenting "late" in the course. I have more concern for azithromycin prolonging the QT interval and leading to torsades than I have for HCQ. The measurable effect to study will be QT prolongation, not arrhythmias, IMO. All preexisting heart issues do not predispose patients to HCQ toxicity or lower the threshold for it, some probably do.
Something that I haven't seen mentioned is the health of those testing positive for the virus and/or antibodies. Does the virus leave behind "underlying conditions". Are victims left with long term issues that could leave them susceptible to serious consequences from a second attack or a case of simple influenza etc.?
QT prolongation is what's being monitored in these CQ and HCQ studies now. I only mention arrhythmia because some of the patients that died in the Brazil study had ventricular tachycardia.
Too early to tell. Pneumonia doesn't usually cause permanent damage.