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COVID-19 Check-in

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Comments

  • dragonslayerdragonslayer ✭✭✭✭✭ Graduate

    Actually, there are reports of pulmonary fibrosis as a result of Covid-19. What we don't know yet is the prevalence. It will takes months or maybe years to accurately determine the answer.

  • Bulldawg1982Bulldawg1982 ✭✭✭✭✭ Graduate

    If memory serves me right, y'all live out in San Diego, correct? Is everybody out there really forced to wear mask? I understand why it's needed but what'll happen if you don't wear one? They fine you? Take ya to jail?

    ...btw, your kids look healthy and happy.

  • christopheruleschristopherules ✭✭✭✭✭ Graduate
    edited April 2020

    @Bulldawg1982 Yes, we are in San Diego and we are all fine. As to your question about the law and masks?, I am not all that certain. However, I DO wear one each and every time that I am outside of our house. Truthfully, I'm much more fearful of my own wife than anyone else (she is an R.N.), that includes law enforcement too!!! LOL Everyone here in San Diego is doing well, the kids are doing their school work with their mother as the adminstrator and teacher's aide (we have an eleven year old fifth grade boy, a nine year old fourth grade girl, a seven year old second grade girl, and a five year old kindergarten boy too) who are all also going stir-crazy, and my wife (I feel) she ought to up for "Sainthood status" after all of this Covid-19 stuff is finally over. I am considered essential personnel at my employer, (but my hours have been reduced) a lot of our staff scientists are working remotely from home. I'd say that the daily San Diego traffic is down 80-85% ??? The population at my work place is probably down to less than 2% of our normal, and my job even gave me a official travel letter to present to law enforcement if I am ever stopped. This has been going on for 6 to 7 weeks, right? I haven't ever been stopped, not once. In fact, I have never had any encounters with any law enforcement at all since the beginning of this around March the 12th. My life nowadays at Salk? It is a ghost town to help us do our part to beat Covid-19.

    PS - GO DAWGS!!!

    https://www.youtube.com/watch?v=wQNkTt-ARBs

  • YaleDawgYaleDawg ✭✭✭✭✭ Graduate

    Have you seen any cases where someone had pulmonary fibrosis caused by COVID-19 but didn't have ARDS?

  • razorachillesrazorachilles ✭✭✭✭✭ Graduate
    edited April 2020

    According to this article, the Brasil study was chloroquine: https://www.theguardian.com/world/2020/apr/24/chloroquine-study-coronavirus-brazil

    I feel that the polarization of hcq as a political topic has clouded the data re: whether anyone can definitively state whether it's effective/safe as a treatment.

    I also feel that a lot of decisions that were made in the fog of war during those early days of the pandemic were a result of governors, hospitals, etc. seeing what was emerging in Europe, saw the early Imperial College models (which were overstated), did the math and said "we're not gonna have enough ventilators" which prompted a chain reaction of misguided strategies and mitigation plans that turned out to not be as important as they expected given the information they had at the time.

    Similarly - there was growing anecdotal experience re: the use of hcq in COVID patients; but as we have since learned in the non-RCT retrospective studies, there was too much variability in when patients initiated treatment. In short - antivirals may potentially help when symptoms first begin (still unproven clinically) but are likely not helpful once patients progress to the severe or critical state. Conversely, studies released this week for an IL-6 blocker indicate that they have no effect for severe patients but may potentially help some critical patients in cytokine storm.

    In other words - retrospective studies for hcq aren't particularly informative as to whether early treatment is effective because it was given to patients at all stages. The reality is that starting a severe or critical patient on hcq is unlikely to reverse the progression because the inflammatory response chain reaction has already passed the point of an antiviral agent being effective.

    One final note: the NIH's official guidance is specific to monitoring for heart issues when using HCQ and for the use HCQ and azithromycin together (and even then - it's still allowed in a controlled study.)

    From the NIH website's therapeutic options section:
    

    There are insufficient clinical data to recommend either for or against using chloroquine or hydroxychloroquine for the treatment of COVID-19 (AIII).

    • If chloroquine or hydroxychloroquine is used, clinicians should monitor the patient for adverse effects, especially prolonged QTc interval (AIII).

    Except in the context of a clinical trial, the COVID-19 Treatment Guidelines Panel (the Panel) recommends against the use of the following drugs for the treatment of COVID-19: the combination of hydroxychloroquine plus azithromycin (AIII) because of the potential for toxicities"

  • mdpuck13mdpuck13 ✭✭✭ Junior
    edited April 2020

    Four elementary age children all doing the "home school" thing and you're both still working? That exhausts me just thinking about it.

    My wife and I are both working from home with two young kids (1 and 3). I try not to complain about it because I recognize that there are a lot of people who are being affected by this virus in ways far worse than us, but man it's difficult trying to keep two young toddlers entertained and out of trouble while still being semi-productive at work.

    So yea...if you're wife is keeping four stir-crazy kids on task with their school while also serving as an R.N....she's definitely a saint and a very strong woman. Take care of her and get her a nice gift once this is all over!

  • Denmen185Denmen185 ✭✭✭✭✭ Graduate
    edited April 2020

    Agreed. I have been wondering if the fatalities in NY would have been less if the bar for hospitalization had not been so high due to shortage of beds/testing! Would earlier treatment with antivirals may have saved some lives?

    The column in green is the deaths as at yesterday as a % of cases as at 10 days prior to account for lag.

  • Denmen185Denmen185 ✭✭✭✭✭ Graduate

    Hope this is clearer


  • razorachillesrazorachilles ✭✭✭✭✭ Graduate

    According to these results, Remdesivir might have made a difference in preventing some patients from progressing to severe/critical

    **

    Dr. Scott Gottlieb, shortly after the Gilead news was released, described remdesivir as “part of a better toolbox” for dealing with the coronavirus. But he said on CNBC’s “Squawk Box” that it’s “not a home run, a cure by any means.”

    “It’s not going to be a cure, but it is going to be a drug potentially that if you use it particularly early in the course of the disease ... it could reduce their chances of having a really bad outcome,” he said.


  • dradcliffdradcliff ✭✭✭✭✭ Graduate

    Why are mask not required everywhere in public? This virus is spread be by fluid from the mouth. If everyone wears a mask, then whether or not I catch it has to do with how good I am with washing my hands or touching my face.

    If everyone does not cover their face then my only choice is to stay isolated.

    Anyone without a mask in public should be given a citation and a mask. The first time could be a warning, then increasing fines, the possible jail time for putting the public at risk.

    The only exceptions should be when eating or drinking. Place with indoor eating and drinking should have warning signs stating the their location is unsafe. When eating outside people should be 15 feet apart unless they live in the same house.

    The only way we can safely go out in public is if others cover their faces. The only way that will happen is if it is required with some type of consequence for noncompliance.

  • RxDawgRxDawg ✭✭✭✭✭ Graduate

    Renal failure. And I'd really like to know why because it doesn't seem to be related to shock.

  • GrayDawgGrayDawg ✭✭✭✭✭ Graduate

    A month ago we were told masks don't help. Now they should be mandated? Scientifically, how did we go from one extreme to the other?

    I'm pretty sure the science is so premature that any strong stance like this is either based in emotion or politics. You daamn well better not mandate something on me based on either of those.

  • Denmen185Denmen185 ✭✭✭✭✭ Graduate

    When walking outside I follow a 20 foot rule as a 10mph wind = air travelling at 14 feet per second. 6 feet is too close in those conditions.

  • pocoyopocoyo ✭✭✭✭✭ Graduate

    Govt. overreach./s. Agree with you. If everyone wore a mask and practiced social distancing we'd get out this a lot quicker.(disclaimer: not a doctor) And it's a hell of a lot better than being shut up at home

This discussion has been closed.